Basic Information
VIS ID
TVIS10012328
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2415
Orient
-
Integrated sequence
TATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCG| |CGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTC
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
GRCh37/hg19
Start
11303/11303 (Hg38)
End
11303/11303 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Downstream/1051593;
Nearest TSS
ENST00000502646/Downstream/80848;
Nearest CpG islands
None/Target, None/Upstream, chr5-CpG: 87/Downstream/39387
Nearby gene
PLEKHG4B(+129070) ;
Upstream sequence
TGGCTGTTAGCTCACACCCATCTTCCTAGTCCTCATGTGTACATACACATTGGCCCAAAGGCAGTCTATAAAGACACAATGGTACTGCGCCTGTCTGCAT
Downstream sequence
aaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaaccctaacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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