Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012334
Fusion event
HBV-PARP8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2135
Orient
+
Integrated sequence
CTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGA| |TCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGA
Host Sequence
Chromosome
chr5
Cytoband
q11.1
Reference genome
Start
End
50110558/50814724 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-10397/Upstream/12257163; hsa-mir-103a-1/Downstream/3136780;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/146781, chr5-CpG: 53/Downstream/154527
Upstream sequence
GGCCGCTGGCCTGATCCGGAGACCCAGGGCTGCCTCCAGGTCCGGACGCGGGGCGTCGGGCTCCGGGCACCACGAATGCCGGACGTGAAGGGGAGGACGG
Downstream sequence
TGCAGAGGCACCGTGGATTGCATCGTGTTAGGCTTCATCAGCTACCTAATGCAATGTAACTTGGGAGATAAGATAAATCAGAGGAATGACACTGTATTAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.