VISDB Viral Integration Site DataBase

VIS ID

TVIS10012335

Fusion event

HBV-ARL15 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2354

Orient

-

Integrated sequence

ATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACG| |ACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAG

Chromosome

chr5

Cytoband

q11.2

Reference genome

Start

End

53184763/53888933 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-let-7b-5p ; hsa-mir-744-5p ; hsa-mir-155-5p ; hsa-mir-142-3p ; hsa-mir-7-5p ; hsa-mir-222-5p ; hsa-mir-3177-5p ; hsa-mir-7110-3p ; hsa-mir-4797-3p ; hsa-mir-4264 ; hsa-mir-936 ; hsa-mir-648 ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-3129-5p ; hsa-mir-6873-3p ; hsa-mir-6817-3p

Nearest miRNA

hsa-mir-10397/Upstream/15331372; hsa-mir-103a-1/Downstream/62571;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/327893, chr5-CpG: 59/Downstream/421169

Upstream sequence

CCGCCCGCACAGGGTGGAGGGCAACCTCGGGGTCCAGGCACCTGGCTCCAAGCCTCGGACTGCAGAGCTAGGAGGCCCGACTTCCAGCCCAGCAGTAGAA

Downstream sequence

GGACCACTGTGCTTACAATGCAATCTAGTATTTGATCAATAATGCTTCCCATCAGATGAAGTATGCAACATCCAAAATCTAGTACATAAAGGAAGTTGTG