Basic Information
VIS ID
TVIS10012344
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1772
Orient
-
Integrated sequence
CTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTG| |TACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCC
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
22671723/22671494 (Hg38)
End
22671723/22671494 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC102724736 ; LOC105374972
Nearest miRNA
hsa-mir-3691/Upstream/4099614; hsa-mir-10398/Downstream/4476132;
Nearest TSS
ENST00000381078/Upstream/77661; ENST00000431001/Downstream/360286;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/101018, chr6-CpG: 23/Downstream/1454587
Nearby gene
HDGFL1(-100973) ; NRSN1(+1454691) ;
Upstream sequence
ggtgcgatctcagctcattgcaacctctgcctcccaggttcaagtgattctcctgcctcagccgcccaagtagctgggattacaggtgcctgccaccacg
Downstream sequence
TATTTGTTTATTTAATTTTTTTTCTTAATGCTATGCAAGTGAACTAAGAAATGATAAGTTTCTGTGCTGCTGGTATTATGTGACTCATTTGAATGCTAAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate