VISDB Viral Integration Site DataBase

VIS ID

TVIS10012345

Fusion event

HBV-GFRAL integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|

Start

1627

Orient

-

Integrated sequence

GCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAAC| |GCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTA

Chromosome

chr6

Cytoband

p12.1

Reference genome

Start

End

55212381/55347583 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-1253 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-5197-3p

Nearest miRNA

hsa-mir-10398/Upstream/2070512; hsa-mir-10524/Downstream/2042549;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/172989, chr6-CpG: 36/Downstream/231351

Upstream sequence

gcgatgcgatctcggctcactgcaatctctgcctcccaggttcaagcaattctcctgcctcagcctcctgagtagctgggactacaggcatacaccaccg

Downstream sequence

aagaaggagaaatgttttataaggatgaataattaatattttggaagctacaaagctggaaaagtagatataaacacattctaatgatatcgtggtatga