Basic Information
VIS ID
TVIS10012347
Fusion event
HBV-LOC101928516 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
75019383/74309667 (Hg38)
End
75019383/74309667 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
LOC101928516
Nearest miRNA
hsa-mir-10398/Upstream/1341914; hsa-mir-10524/Downstream/1118740;
Nearest TSS
ENST00000381078/Upstream/240216; ENST00000421318/Downstream/285546;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/613256, chr6-CpG: 28/Downstream/775497
Nearby gene
CD109(-481342) ; COL12A1(+774659) ;
Upstream sequence
CCTGTTGTCAGTTGGTCTAGTGCAGGTATACTTCAAATTCCATAGCCACCTCTCACAGTATTTTGTTGCTTTTGATTAAAAAAAAGTTGGCACGTGTGGA
Downstream sequence
TGTCTCCACAAAGTTGTCAGATATTTGGACCTATTCTTCATACGATGAACATTACTAACTGCCTTTAGTCCCAGTAGGAACTATGTGCTTGCACTGAAGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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