Basic Information
VIS ID
TVIS10012348
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1752
Orient
-
Integrated sequence
TACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGA| |GATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTT
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
82967849/82258132 (Hg38)
End
82967849/82258132 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/3718823; hsa-mir-1202/Downstream/8054610;
Nearest TSS
ENST00000381078/Upstream/10378; ENST00000535040/Downstream/105074;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/10007, chr6-CpG: 174/Downstream/105567
Nearby gene
IBTK(-10401) ; TPBG(+105074) ;
Upstream sequence
TGATACTAGGCATTTAAAAACATTCAGTTTTCATAGGATAATTGTGAACATTAATTTGTATATAATTTCAGTAATTTGAATTCAATTGAAGAACATATTG
Downstream sequence
aaaaatacaaaaaattaaaaaaaaaaaaagaaaaaaatacagaaaattagccgggcgtggtggcacacacctgtagtcgcagctacttgggaagctgagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate