ZFAT _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012353
Fusion event
HBV-ZFAT integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1835
Orient
+
Integrated sequence
GAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTG| |CCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCT
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
135525404/134513161 (Hg38)
End
135525404/134513161 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZFAT
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1204/Upstream/1466580; hsa-mir-10400/Downstream/287359;
Nearest TSS
ENST00000518652/Upstream/2079; ENST00000505776/Downstream/52510;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/34318, chr8-CpG: 82/Downstream/199366
Upstream sequence
GCCACAGATTCTGTCCTACCACAGATGTCTCAAGTACAATGCTGAAACCAAGTTAGATACCTAAACACATCTCTTCCTATGTGACAATCCAGAACGAATA
Downstream sequence
CAGAGTAAGAGTTCAGAAAATCTTAGCTATTTGTGCttttttttttttttttttgagacagagtctcgctctgtcacccaggctggagcgcggtggcgcg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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