Basic Information
VIS ID
TVIS10012355
Fusion event
HBV-LOC107986923 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
409
Orient
+
Integrated sequence
AATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCT| |TCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCAC
Host Sequence
Chromosome
chr8
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
21728299/21870788 (Hg38)
End
21728299/21870788 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107986923
Nearest miRNA
hsa-mir-124-1/Upstream/4189131; hsa-mir-10400/Downstream/374178;
Nearest TSS
ENST00000518652/Upstream/58431; ENST00000520754/Downstream/40287;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/80455, chr8-CpG: 35/Downstream/41395
Nearby gene
GFRA2(-81953) ; DOK2(+38085) ;
Upstream sequence
CAATCCTACGttcactcattcattcattcattcattcattcaGcaaacatttactgagtgcatattatatgagaggatttgttctaccagtgggagttca
Downstream sequence
AGACTTCTCACCCAGCACAGTGCGTAGACATGAGTAGGAATATCAGACTGAACCCTTCAGGATCAGATACAGGGGGAGGGCAAACAATGTAAAAGGAATA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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