Basic Information
VIS ID
TVIS10012360
Fusion event
HBV-CNBD1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2330
Orient
+
Integrated sequence
TTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACT| |TCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCT
Host Sequence
Chromosome
chr8
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
87940598/86928370 (Hg38)
End
87940598/86928370 (Hg38)
Orient
+
Location type
Intronic
Target gene
CNBD1
Nearest miRNA
hsa-mir-12123/Upstream/6686897; hsa-mir-10400/Downstream/4277115;
Nearest TSS
ENST00000518652/Upstream/61925; ENST00000522105/Downstream/116122;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/413326, chr8-CpG: 25/Downstream/945573
Upstream sequence
GAAAGTCGTTAGGGTATATGTAGGTCAGAGCCAGGGCCGCTGCGTGCACAGAGGTGTGTCATGGAGCGGCCAGTAGGCACCAAAATCCAGCCAAAGCTCG
Downstream sequence
taagtgcctcttgagtatttcatttacctccttgaccttccctgaggattgtggtctccaggcacagtgaaggttatattgtatccctagcgccctggaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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