Basic Information
VIS ID
TVIS10012365
Fusion event
HBV-LOC107987080 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1972
Orient
-
Integrated sequence
TCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCT| |TTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCA
Host Sequence
Chromosome
chr9
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
77849725/75234809 (Hg38)
End
77849725/75234809 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC107987080
Nearest miRNA
hsa-mir-101-2/Upstream/4424725; hsa-let-7a-1/Downstream/8734939;
Nearest TSS
ENST00000422679/Upstream/146266; ENST00000455583/Downstream/344860;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/145906, chr9-CpG: 148/Downstream/655505
Nearby gene
OSTF1(-87611) ; MIR548H3(+268787) ;
Upstream sequence
atttgcatttctctaatgaccagtgatgatgagctttttttcatatgtatgttgccggcgtatggcagcataaatgccttttgagaagtgtctgttcata
Downstream sequence
tatttttttaaaagttcccagatgCAGTAAGGATTTATTAAAGCATAAATCCTACTGGGTGCTAGGCAGCACAGCTGCACACTCAGGGATTGAATGATCA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate