Basic Information
VIS ID
TVIS10012368
Fusion event
HBV-chrX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1767
Orient
-
Integrated sequence
TTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGT| |CTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTC
Host Sequence
Chromosome
chrX
Cytoband
p22.13
Reference genome
GRCh37/hg19
Start
17907882/17889762 (Hg38)
End
17907882/17889762 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-3690-1/Upstream/463808; hsa-let-7f-2/Downstream/2127326;
Nearest TSS
ENST00000429181/Upstream/28425; ENST00000636046/Downstream/214882;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/28621, chrX-CpG: 42/Downstream/330350
Nearby gene
RAI2(-28425) ; BEND2(+273169) ;
Upstream sequence
caacattagacagatcaacgagacagaaagttaacaaggatatccaggaattgaactcagctctgcaccaagaagacctaatagacatctacagaactct
Downstream sequence
aagcagaaagaaggaaataatcagagcaaaaaaaaaaaaaaaaatcaatgaaattgacaacaacaaaaaacaatagagaaaatcaatgaaacaaaaaagc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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