Basic Information
VIS ID
TVIS10012377
Fusion event
HBV-FAM157C integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
722
Orient
-
Integrated sequence
GGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCAC| |TGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTT
Host Sequence
Chromosome
chr16
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
90188357/90121949 (Hg38)
End
90188357/90121949 (Hg38)
Orient
+
Location type
Intronic
Target gene
FAM157C
Nearest miRNA
hsa-mir-11401/Upstream/1405612;
Nearest TSS
ENST00000527434/Upstream/15488; ENST00000566898/Downstream/4073;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/15432, chr16-CpG: 34/Downstream/49383
Nearby gene
PRDM7(-46019) ;
Upstream sequence
atttagggttcaggtttatggttcgggttagggttcaggttagggtttgggttgggtttagggttagggtttagggttagggtttgggttaggggttagg
Downstream sequence
ggttagggttaggggtgagggtgagggtgaggatgagggttaaggtttaagggttaagggttaggggttagggttagggttaagggtcagggtcaggggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate