Basic Information
VIS ID
TVIS10012378
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
722
Orient
-
Integrated sequence
GGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCAC| |TGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTT
Host Sequence
Chromosome
chr17
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
81195057/83247288 (Hg38)
End
81195057/83247288 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10226/Upstream/578981;
Nearest TSS
ENST00000595228/Upstream/19567;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/29808, None/Downstream
Nearby gene
RPL23AP87(-6484) ;
Upstream sequence
tagggctagggctagggctagggctagggctagggtttagggttagggttagggttagggttagggttagggttaggttagggtgagggtgagggtgagg
Downstream sequence
gtgagggtgagggtgagggtgagggtttagggttggggttggggttggggttggggttggggttggggttagggttagggttagggttagggttagggtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate