Basic Information
VIS ID
TVIS10012388
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1772
Orient
-
Integrated sequence
CTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTG| |TACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCC
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
12143950/12240633 (Hg38)
End
12143950/12240633 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA17A
Nearest miRNA
hsa-mir-1253/Upstream/158637; hsa-mir-10226/Downstream/676635;
Nearest TSS
ENST00000595228/Upstream/39033; ENST00000577679/Downstream/309149;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/219079, chr17-CpG: 70/Downstream/424717
Nearby gene
MAP2K4(-96899) ; LINC00670(+309335) ;
Nearest cancer related gene
MAP2K4(TSG, -96899) ;
Upstream sequence
ttgtcttttcttctctattcattggaattgagccactaggtGATTTGTGATTTCTAGTTCCATCCTTTAGAATGACTTAGACATTTTTGTTTGTTTGTTT
Downstream sequence
GCATGAAAGTTCCAAATaattcactgataacaccatctgggcctaaagtctttttggaggtaaaattttaaaAACCTTTTAAAAGAATTTTCATGATTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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