Basic Information
VIS ID
TVIS10012389
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
X protein|precore/core protein|
Start
1827
Orient
-
Integrated sequence
AAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTT| |CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
End
12143967/12240650 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-1253/Upstream/158654; hsa-mir-10226/Downstream/676618;
Nearby gene
MAP2K4(-96916) ; LINC00670(+309318) ;
Nearest cancer related gene
MAP2K4(TSG, -96916) ;
Upstream sequence
ttcattggaattgagccactaggtGATTTGTGATTTCTAGTTCCATCCTTTAGAATGACTTAGACATTTTTGTTTGTTTGTTTGCATGAAAGTTCCAAAT
Downstream sequence
aattcactgataacaccatctgggcctaaagtctttttggaggtaaaattttaaaAACCTTTTAAAAGAATTTTCATGATTTCTTctgggtgtgatggct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate