Basic Information
VIS ID
TVIS10012391
Fusion event
HBV-KLF3-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2463
Orient
+
Integrated sequence
GTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTG| |GACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACAC
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
38649479/38647858 (Hg38)
End
38649479/38647858 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
KLF3-AS1
Nearest miRNA
hsa-mir-12113/Upstream/1405867; hsa-mir-1243/Downstream/220174;
Nearest TSS
ENST00000502981/Upstream/28421; ENST00000482150/Downstream/16338;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/633038, chr4-CpG: 164/Downstream/15170
Upstream sequence
TGGGCGGGGCCTGCACAGAGTAGAGGGTAAGTggggccagcgcaggggagggggctgtggcgttggcataggggagagggtgagcggggccagtgcaggg
Downstream sequence
GCTGGGCATTTCCTTCCCAAGGCTTCATACTATTCCTCTTGCCACTTGttctttttcttgtttttgagactgggtcttactctcttgcccaggctggaat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate