Basic Information
VIS ID
TVIS10012393
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2069
Orient
+
Integrated sequence
TCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAG| |GCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTC
Host Sequence
Chromosome
chr6
Cytoband
q16.1
Reference genome
GRCh37/hg19
Start
93502091/92792373 (Hg38)
End
93502091/92792373 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA6G
Nearest miRNA
hsa-mir-10398/Upstream/1270636; hsa-mir-1202/Downstream/5232158;
Nearest TSS
ENST00000381078/Upstream/68544; ENST00000452624/Downstream/278014;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2180873, chr6-CpG: 92/Downstream/624181
Nearby gene
MIR4643(-1270636) ; EPHA7(+447649) ;
Upstream sequence
agctcactgcaaattccgcctcccaggttcaagtaattctcctgcctcaggttcccaagcagttgggactacaggcatgtaccaccatgcccagctaact
Downstream sequence
GCTTGTATTATGTTTAATACTGACTATGACATATTCTGAAAATTATTTTTTCTTATTGATATTTAAAAAGTTATATTCTTATTGATGACATAATTTCTTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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