Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012394
Fusion event
HBV-FBXL13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
Polymerase|large S protein|
Start
3135
Orient
+
Integrated sequence
CTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCC| |CGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
End
102684581/103044134 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
miRNAs that regulate target gene
hsa-mir-4477a ; hsa-mir-9-3p ; hsa-mir-590-5p ; hsa-mir-21-5p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-5096 ; hsa-mir-3149 ; hsa-mir-6855-5p ; hsa-mir-3170 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-197-3p ; hsa-mir-4775 ; hsa-mir-193b-5p ; hsa-mir-4755-3p ; hsa-mir-4735-5p ; hsa-mir-4716-5p ; hsa-mir-4781-3p ; hsa-mir-6890-5p ; hsa-mir-941 ; hsa-mir-590-3p ; hsa-mir-4662b ; hsa-mir-4647 ; hsa-mir-4426
Nearest miRNA
hsa-mir-10525/Upstream/572603; hsa-mir-10399/Downstream/11609211;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/294668, chr7-CpG: 90/Downstream/30525
Nearest cancer related gene
FBXL13(TSG, No orient, 0)
Upstream sequence
tctcttttttctttctttctttcttatttcgtctttcttctttcttctttctctttctttctttctctctttcttttctttctttttttttttttttttt
Downstream sequence
gaaatacgggaaacagagtaagtaaaatgacactagaggaagcattgagaacctgggacattttacaagacaaattacccgtttccttcaataaataagt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.