Basic Information
VIS ID
TVIS10012396
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1474
Orient
+
Integrated sequence
CATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCG| |CTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCG
Host Sequence
Chromosome
chr13
Cytoband
q12.11
Reference genome
GRCh37/hg19
Start
20961881/20387742 (Hg38)
End
20961881/20387742 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1267/Downstream/46036;
Nearest TSS
ENST00000623511/Upstream/155347; ENST00000389373/Downstream/52162;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/85667, chr13-CpG: 57/Downstream/4077
Nearby gene
GJB6(-155347) ; CRYL1(+15925) ;
Upstream sequence
GCGCCGGGAAGCTTGAGCAGGATTTGGGCATTCTGACATGGGGAAGGCATTACCTTCTTCCCCTTTAGTTGTGTCTGGCACATGGACTCAGCAGAGGCTG
Downstream sequence
TTGGGAATGTTCTGAGATCACATACCAGCAGCCTCCTAACCCAAGCCGACCCAAAAGAGACATGCCCCCAAGAAAGGATTCCGGACTGCACCTGGTGGCC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate