Basic Information
VIS ID
TVIS10012405
Fusion event
HBV-LOC105371082 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1806
Orient
-
Integrated sequence
ACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGC| |ACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGG
Host Sequence
Chromosome
chr16
Cytoband
p13.13
Reference genome
GRCh37/hg19
Start
11433760/11339903 (Hg38)
End
11433760/11339903 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105371082
Nearest miRNA
hsa-mir-1225/Upstream/33376; hsa-mir-11401/Downstream/1380418;
Nearest TSS
ENST00000527434/Upstream/27003; ENST00000576027/Downstream/5294;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/63539, chr16-CpG: 78/Downstream/5426
Nearby gene
PRM1(-58568) ; RMI2(+5551) ;
Upstream sequence
atttcttgttgcatttcaaagtaagttgcatccaaagtaagtaagagacatccatccactgcccctttgcatactttggcaggcatttcattaaatacag
Downstream sequence
ttcaaaatttgtGTGCGTGTATGTGTGTGTTTTCATAAAACCTGTATTTCCAAAAAAAAAATTCCCCAGAGTATTCTTCCACGGTGCCAATCCAGGATAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate