Basic Information
VIS ID
TVIS10012409
Fusion event
HBV-LINC00486 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
100
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGA| |CTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTT
Host Sequence
Chromosome
chr2
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
33141301/32916234 (Hg38)
End
33141301/32916234 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
LINC00486
Nearest miRNA
hsa-mir-1301/Upstream/280903; hsa-mir-10b/Downstream/502282;
Nearest TSS
ENST00000437798/Upstream/33433; ENST00000440786/Downstream/10893;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/288031, chr2-CpG: 164/Downstream/30147
Upstream sequence
ctttccttcctccctccctccctcccccttacctccctgccttccttccGGCGGGCGTACTTGCGGGCGGGCGGGGCTGCgggggggcgtgggtaggggg
Downstream sequence
ggggggtggggggggggcggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggggga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate