Basic Information
VIS ID
TVIS10012411
Fusion event
HBV-LOC107986663 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1918
Orient
+
Integrated sequence
CAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTT| |ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG
Host Sequence
Chromosome
chr6
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
158123774/157702742 (Hg38)
End
158123774/157702742 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107986663
Nearest miRNA
hsa-mir-10398/Upstream/173542; hsa-mir-1913/Downstream/906965;
Nearest TSS
ENST00000381078/Upstream/2355; ENST00000614800/Downstream/13304;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/29694, chr6-CpG: 171/Downstream/119827
Nearby gene
ZDHHC14(-28797) ; SNX9(+120520) ;
Upstream sequence
atatttaatgtgtacaatttgacatatttggacatatacatatacccataaaaccattacaacaatcgagataatgagtacatcacccccagtagattct
Downstream sequence
acggagacatgatggctaggctaaaacagtaaggtcaagttgtttggacagaaaggctacagggtgcggtcctggctcttgtgtaagaattctgaccgca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate