Basic Information
VIS ID
TVIS10012413
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2041
Orient
+
Integrated sequence
GAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGC| |ATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGC
Host Sequence
Chromosome
chr15
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
84297339/83628587 (Hg38)
End
84297339/83628587 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/561172; hsa-mir-11181/Downstream/1752009;
Nearest TSS
ENST00000557528/Upstream/19184; ENST00000565653/Downstream/25499;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/180418, chr15-CpG: 159/Downstream/24983
Nearby gene
SH3GL3(-9846) ; ADAMTSL3(+25499) ;
Upstream sequence
atcccagcattttgggaggccaacgtaggtggatcacatgaggtcaggagtccgagaccagcctggccaacatggtgaaaccctatttctactaaaagta
Downstream sequence
caaaaatcagctatgagtggtggcaggtgcctgtaatcccagctactcaggaagctgaggcaggagaattgcttgaacctgggaggtggagattacagtg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate