Basic Information
VIS ID
TVIS10012416
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2250
Orient
+
Integrated sequence
CCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATA| |GAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTA
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
81425443/80851308 (Hg38)
End
81425443/80851308 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/3153192; hsa-mir-1267/Downstream/6767357;
Nearest TSS
ENST00000623511/Upstream/510357; ENST00000456588/Downstream/192362;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/195998, chr13-CpG: 18/Downstream/3028221
Nearby gene
SPRY2(-510357) ;
Nearest cancer related gene
SPRY2(TSG, -510357) ;
Upstream sequence
tgagaatataaggaaataaacaatttttgttaaaccagtacaatgtgttaaaattacacattttatacaatttacacattttaaacaatgtgtaattaca
Downstream sequence
agagtaaaaaaatcaaaagttaaagtaaaaacattacagtaatctaaggctaatttattatttaagaaatacatttacaaaataaatttagtgtagccta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate