Basic Information
VIS ID
TVIS10012417
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2111
Orient
+
Integrated sequence
TGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTAC| |CTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTT
Host Sequence
Chromosome
chr15
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
84297364/83628612 (Hg38)
End
84297364/83628612 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/561197; hsa-mir-11181/Downstream/1751984;
Nearest TSS
ENST00000557528/Upstream/19209; ENST00000565653/Downstream/25474;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/180443, chr15-CpG: 159/Downstream/24958
Nearby gene
SH3GL3(-9871) ; ADAMTSL3(+25474) ;
Upstream sequence
taggtggatcacatgaggtcaggagtccgagaccagcctggccaacatggtgaaaccctatttctactaaaagtacaaaaatcagctatgagtggtggca
Downstream sequence
ggtgcctgtaatcccagctactcaggaagctgaggcaggagaattgcttgaacctgggaggtggagattacagtgagctgagatcacgccattcactgcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate