Basic Information
VIS ID
TVIS10012419
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1817
Orient
+
Integrated sequence
TGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCAT| |GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT
Host Sequence
Chromosome
chr20
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
6816618/6835971 (Hg38)
End
6816618/6835971 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/2918400; hsa-mir-1-1/Downstream/535637;
Nearest TSS
ENST00000382410/Upstream/68307; ENST00000425900/Downstream/233643;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/65661, chr20-CpG: 96/Downstream/1183171
Nearby gene
BMP2(-55708) ; HAO1(+1047013) ;
Nearest cancer related gene
BMP2(TSG, -55708) ;
Upstream sequence
TGAGCATAATATCCTCACCTTTCAAGATATCACATAACTCTTGCTTATTTAACAGGGAAAAAAAACCCCAAACCCCAAAAAAACCTCTAACCAAACACGA
Downstream sequence
ACATGACACTCTTAGATCAAATTGTGCTCCTGGCTATTTCTGAATAAGTCCAAGTAACACATGGTTAGTGGGATATTTTAGTTGCCGAGATGGCATTCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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