SORBS2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012421
Fusion event
HBV-SORBS2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3155
Orient
+
Integrated sequence
GGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGA| |AACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
GRCh37/hg19
Start
186672842/185751688 (Hg38)
End
186672842/185751688 (Hg38)
Orient
-
Location type
Intronic
Target gene
SORBS2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1226-3p ; hsa-mir-129-5p ; hsa-mir-3152-5p ; hsa-mir-4774-3p ; hsa-mir-6836-3p ; hsa-mir-3671 ; hsa-mir-139-3p ; hsa-mir-372-5p ; hsa-mir-4254 ; hsa-mir-3690 ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-660-3p
Nearest miRNA
hsa-mir-12113/Upstream/813248;
Nearest TSS
ENST00000502981/Upstream/11358; ENST00000456728/Downstream/9902;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/112481, chr4-CpG: 123/Downstream/352890
Upstream sequence
aaaagtctgtttgttctccctttatctttgccatgattgtgaggcctccccagccatgtggaactgtgattaaattaaacctctttcctttgtaaatttc
Downstream sequence
CATCAGAGGGGAGAGGAAATACAGGGAGAAGGGAAGTCAAGGAAAGATGCCTGACATTCCACAGGAGAAGCTTCTGCACAGGAGCAGTGGGGATAACAAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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