Basic Information
VIS ID
TVIS10012425
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2469
Orient
+
Integrated sequence
TAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCA| |TAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGAC
Host Sequence
Chromosome
chr5
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
102591904/103256203 (Hg38)
End
102591904/103256203 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA5F
Nearest miRNA
hsa-mir-10397/Upstream/2439638; hsa-mir-103a-1/Downstream/7257626;
Nearest TSS
ENST00000502646/Upstream/2684; ENST00000515669/Downstream/2499;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/135917, chr5-CpG: 107/Downstream/2531
Nearby gene
PPIP5K2(-52995) ; C5orf30(+2538) ;
Upstream sequence
tctggccccagccatctctccagcctcatttctgGTGACTCCCAGATCTGGCCCCAGCCATGTCTCTAGACTCCAAACTTATTCCTTATAATGCTCCCAC
Downstream sequence
gattggagggcaggagaggagaacgtatagtacatttcccccttctccctccctagattgcttctttggcagtggttgtttctcctctatggccgcagct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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