Basic Information
VIS ID
TVIS10012428
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1700
Orient
-
Integrated sequence
GCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTG| |AGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGT
Host Sequence
Chromosome
chr6
Cytoband
q27
Reference genome
GRCh37/hg19
Start
165624152/165210663 (Hg38)
End
165624152/165210663 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/6445910; hsa-mir-1913/Downstream/1298691;
Nearest TSS
ENST00000381078/Upstream/382913; ENST00000435810/Downstream/71359;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/873316, chr6-CpG: 31/Downstream/123611
Nearby gene
QKI(-1624524) ; C6orf118(+69001) ;
Upstream sequence
cccacacaataataatgggagactttaacaacccactgtcaacattagacagatcaatgagacagaaaattaaaaaggatatccaggaattgaactcagc
Downstream sequence
ACAGTCTTAGAGAAGAGGAAAGGTGAGTTCCCGAGATGTTTTCCACCCAATAATCATTAATCAAGCAGCAGAAGTAAAGCCACAATGAAGGTCTCCTGAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate