Basic Information
VIS ID
TVIS10012429
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2035
Orient
-
Integrated sequence
ACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTC| |CTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGA
Host Sequence
Chromosome
chr6
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
26291671/26291443 (Hg38)
End
26291671/26291443 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6C
Nearest miRNA
hsa-mir-3691/Upstream/7719563; hsa-mir-10398/Downstream/856183;
Nearest TSS
ENST00000381078/Upstream/5805; ENST00000528222/Downstream/73716;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/5731, chr6-CpG: 18/Downstream/166639
Nearby gene
HIST1H4H(-5944) ; BTN3A2(+73727) ;
Upstream sequence
cccacacattaatagtgggagactttaacaccccactgtcaacattagacagatcaaagagacagaaagttaacaaggatatccaggaattgaactcagc
Downstream sequence
aggagataaagccgtgagctctaaaacctgaataactgcgattaactctgagcattgagctgaaactccagagatctttattgtttgagtatgtttagtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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