VISDB Viral Integration Site DataBase

VIS ID

TVIS10012462

Fusion event

HBV-BMPR1A integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

234

Orient

+

Integrated sequence

GATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTC| |ACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATC

Chromosome

chr10

Cytoband

q23.2

Reference genome

Start

End

88541372/86781615 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-455-3p ; hsa-mir-656-3p ; hsa-mir-580-3p ; hsa-mir-548l ; hsa-mir-510-3p ; hsa-mir-431-5p ; hsa-mir-3140-3p ; hsa-mir-203a-3p ; hsa-mir-302f ; hsa-mir-3616-5p ; hsa-mir-573 ; hsa-mir-34a-3p ; hsa-mir-1264 ; hsa-mir-574-5p ; hsa-mir-1277-5p ; hsa-mir-190a-3p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-5585-3p ; hsa-mir-5011-5p ; hsa-mir-511-3p ; hsa-mir-1273e ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-4459 ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-4521 ; hsa-mir-34c-3p ; hsa-mir-1197 ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-8485 ; hsa-mir-6816-3p ; hsa-mir-8080 ; hsa-mir-139-3p ; hsa-mir-8055 ; hsa-mir-6739-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-6770-5p ; hsa-mir-1253 ; hsa-mir-9500 ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-5584-5p ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-4695-3p ; hsa-mir-4772-3p ; hsa-mir-1281 ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-660-3p ; hsa-mir-4485-5p ; hsa-mir-6736-3p ; hsa-mir-6890-3p ; hsa-mir-6513-3p ; hsa-mir-8062 ; hsa-mir-4755-5p ; hsa-mir-5006-3p ; hsa-mir-6832-3p ; hsa-mir-623 ; hsa-mir-5692a ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-4762-3p ; hsa-mir-3192-3p ; hsa-mir-29a-5p ; hsa-mir-3920 ; hsa-mir-6787-3p ; hsa-mir-1304-3p ; hsa-mir-1237-3p ; hsa-mir-885-3p ; hsa-mir-1247-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-4279 ; hsa-mir-450b-3p ; hsa-mir-4713-3p ; hsa-mir-4722-3p ; hsa-mir-6086 ; hsa-mir-6134 ; hsa-mir-619-5p ; hsa-mir-638 ; hsa-mir-6506-5p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6802-3p ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-769-3p ; hsa-mir-7847-3p

Nearest miRNA

hsa-mir-1265/Upstream/516827; hsa-mir-107/Downstream/722266;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/24155, chr10-CpG: 108/Downstream/160943

Nearest cancer related gene

BMPR1A(TSG, No orient, 0)

Upstream sequence

tggttctgtacaaattttaggatttgtttttccgtgaagaatgtcattggtattttgatagggattgcattggatctgtagattgctttgtgtagtattt

Downstream sequence

ctggcactttctcatcttgcctgactgaaactctgtactttagagcaactccctatttccctctcccttcagctcctggcaaccaccagtctaccatttt