SORL1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012463
Fusion event
HBV-SORL1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
312
Orient
-
Integrated sequence
TTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAAT| |TCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCA
Host Sequence
Chromosome
chr11
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
121351965/121481256 (Hg38)
End
121351965/121481256 (Hg38)
Orient
+
Location type
Intronic
Target gene
SORL1
miRNAs that regulate target gene
hsa-mir-127-5p ; hsa-mir-1229-3p
Nearest miRNA
hsa-mir-10392/Upstream/2168244; hsa-let-7a-2/Downstream/618501;
Nearest TSS
ENST00000527297/Upstream/28243; ENST00000524873/Downstream/73786;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/28663, chr11-CpG: 113/Downstream/1174314
Upstream sequence
CGTAGTGCACAGATACCTATAGGCAGGCTCCATCTCCTCCTCCCCAGCTCCTCTCCTAGTGCACAGATACCTATAGGCAAGCTCCATCTCCTCCTCCCCA
Downstream sequence
GCTCCTCCCCTAGTGCACAGATACCTATAGGCAGGCTCCATCTCCTCCTCCCCAGCTCCTCCCCTAGTGCACAGATACCTATAAGCAAGCTCCATCTCCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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