Basic Information
VIS ID
TVIS10012465
Fusion event
HBV-LOC105376607 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1574
Orient
+
Integrated sequence
CTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCG| |GACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACT
Host Sequence
Chromosome
chr11
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
30193847/30172300 (Hg38)
End
30193847/30172300 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105376607
Nearest miRNA
hsa-mir-210/Upstream/1694752; hsa-let-7a-2/Downstream/4769537;
Nearest TSS
ENST00000527297/Upstream/87957; ENST00000533718/Downstream/58716;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/153553, chr11-CpG: 37/Downstream/150689
Nearby gene
KCNA4(-155270) ; FSHB(+58716) ;
Upstream sequence
aagcaggttcagaggggttaactttcactaggcacacagctattaagtggtggagttgagatttaaacccacgcaatcagctctagagtctttgcctaca
Downstream sequence
ggcagtacaccatactgCCTATACCAACATGAGCATGAACTCCAGGATATCAACTTTATTATTCCTTTTTTATTGCCATCACTCCCCTCAGCAACAGGAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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