VISDB Viral Integration Site DataBase

VIS ID

TVIS10012474

Fusion event

HBV-NBEA integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

418

Orient

+

Integrated sequence

TCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGC| |TGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATG

Chromosome

chr13

Cytoband

q13.3

Reference genome

Start

End

35713412/35139275 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-548b-3p ; hsa-mir-335-5p ; hsa-mir-9-5p ; hsa-mir-128-3p ; hsa-mir-21-5p ; hsa-mir-935 ; hsa-mir-18a-5p ; hsa-mir-377-3p ; hsa-mir-485-3p ; hsa-mir-127-3p ; hsa-mir-409-5p

Nearest miRNA

hsa-mir-2276/Upstream/10976771; hsa-mir-1267/Downstream/4524759;

Nearest TSS

Nearest CpG islands

None/Target, chr13-CpG: 551/Upstream/195985, chr13-CpG: 54/Downstream/331432

Upstream sequence

tcagcctcccaagtagctgggactataggtgcatgccaccacacctagctaatttttgtatttttagtgtagatggggtttcaccatgttggccatgctg

Downstream sequence

gtcttgaactcctgacctcaagtgatccgcctgcctcggcctcccaaagtgttgggattacaggcatgagccaccacacccagcAATAAGAAGTATCTTT