Basic Information
VIS ID
TVIS10012476
Fusion event
HBV-chr13 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
418
Orient
+
Integrated sequence
TCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGC| |TGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATG
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
80983773/80409638 (Hg38)
End
80983773/80409638 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1297/Upstream/2711522; hsa-mir-1267/Downstream/7209027;
Nearest TSS
ENST00000623511/Upstream/68687; ENST00000456588/Downstream/634032;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/66552, chr13-CpG: 31/Downstream/245274
Nearby gene
SPRY2(-68687) ;
Nearest cancer related gene
SPRY2(TSG, -68687) ;
Upstream sequence
cctgagtagctgggacctgggactacaggcacgtaccaccacacctagctaatttttgtatatttagtagagatggggtttcaccatgttggccaggctg
Downstream sequence
gtcttgaactcctgacctcaagggatccacctgcctcggcctcccaaagtgctgggattataagcatgagcccctgcacccagccTTGTTCCAGTGTTTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate