Basic Information
VIS ID
TVIS10012479
Fusion event
HBV-chr15 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1815
Orient
-
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chr15
Cytoband
q26.1
Reference genome
GRCh37/hg19
Start
90475471/89932239 (Hg38)
End
90475471/89932239 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10393/Upstream/48209; hsa-mir-1302-10/Downstream/74516;
Nearest TSS
ENST00000557528/Upstream/19283; ENST00000559419/Downstream/69153;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/19208, chr15-CpG: 45/Downstream/67939
Nearby gene
ARPIN-AP3S2(-19249) ; ZNF710(+69281) ;
Upstream sequence
gtcataaaagaagtcaaggcagtcttaactaatggaaacccttctgccagactgtctaatggcaatttgttttctggcattgctgcttcaatgtcatctt
Downstream sequence
cctcatcgtctgggagcactcatctccatcaagatgtcttGAATCAGCAGCTTATGTTTTTAGCTTTTTCTTGCTCCTAAGTGTTGGTGGTCTTCCAGAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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