Basic Information
VIS ID
TVIS10012480
Fusion event
HBV-LOC400499 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2002
Orient
-
Integrated sequence
ATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCG| |CCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGAC
Host Sequence
Chromosome
chr16
Cytoband
p13.13
Reference genome
GRCh37/hg19
Start
11586597/11492741 (Hg38)
End
11586597/11492741 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC400499
Nearest miRNA
hsa-mir-1225/Upstream/186214; hsa-mir-11401/Downstream/1227580;
Nearest TSS
ENST00000527434/Upstream/986; ENST00000329565/Downstream/30847;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/146831, chr16-CpG: 31/Downstream/1022
Nearby gene
RMI2(-140980) ; LITAF(+54981) ;
Upstream sequence
gggcgtggtggcgggcacctgtagtcccacctactcaggaggctgaggcaggagaatggcgtgaacccaggaggcagagcttgcagtgagcggagatggt
Downstream sequence
gacaccgcactccagcctgggtgacagagtgagactccgtctcaaaaaaaaaaaaagttaggtggtaataaaccctaaggaagggaaaatgaaatgggga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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