Basic Information
VIS ID
TVIS10012484
Fusion event
HBV-chr17 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2354
Orient
+
Integrated sequence
ATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACG| |ACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAG
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
14984304/15080987 (Hg38)
End
14984304/15080987 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA17A
Nearest miRNA
hsa-mir-1253/Upstream/1537341; hsa-mir-10226/Downstream/170640;
Nearest TSS
ENST00000595228/Upstream/50012; ENST00000579159/Downstream/25200;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/735583, chr17-CpG: 77/Downstream/179626
Nearby gene
CDRT7(-49030) ; PMP22(+148792) ;
Upstream sequence
GCTCAAGGAAAGTCTCTCTCTTTTTTAATGAGATATACCTACTGTTTGTCTTCATcagtggtgcgttggtaaatgcttaacaatgggcgctcagagggaa
Downstream sequence
agctctgttgtgtagcattagccagtctctgcagtgtaaatactctcacggggtatgtaatttcaagctatacatgtgaaatcactggatgtggacttgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate