VISDB Viral Integration Site DataBase

VIS ID

TVIS10012491

Fusion event

HBV-TWSG1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

418

Orient

+

Integrated sequence

TCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGC| |TGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATG

Chromosome

chr18

Cytoband

p11.22

Reference genome

Start

End

9373331/9373333 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-577 ; hsa-mir-142-3p ; hsa-mir-155-5p ; hsa-mir-4291 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6778-3p ; hsa-mir-149-5p ; hsa-mir-106b-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-545-3p ; hsa-mir-892b ; hsa-mir-3591-3p ; hsa-mir-21-3p

Nearest miRNA

hsa-mir-3976/Upstream/2998908; hsa-mir-1-2/Downstream/1386251;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/37972, chr18-CpG: 105/Downstream/101473

Upstream sequence

aacagcattaaactatgtaaggcagggccaggtgcagtggctcatgccactttgggaggctgaggcaggtggatcacttgagggcaggagttcaagacca

Downstream sequence

gcctggtcaacatggcgaaaccctgtctctaccaaaaaaaaaatacaaaaattagctgggcatagtggtgcatgcctataatcccagctacttgggatgc