Basic Information
VIS ID
TVIS10012495
Fusion event
HBV-LOC105373691 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
984
Orient
+
Integrated sequence
TATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAGGCCTATTGATTGGA| |AAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCATGTATTCAATCTAA
Host Sequence
Chromosome
chr2
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
153875776/153019262 (Hg38)
End
153875776/153019262 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC105373691
Nearest miRNA
hsa-mir-128-1/Upstream/1650851; hsa-mir-10b/Downstream/6167573;
Nearest TSS
ENST00000437798/Upstream/299095; ENST00000429916/Downstream/182464;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/300223, chr2-CpG: 88/Downstream/458673
Nearby gene
ARL6IP6(-258009) ; RPRM(+458076) ;
Upstream sequence
cacaattatagtggagggtgaaaggcacatgttacatgacagtaaacaagagggagagcttgtgcagggagactcccatttttaaaaccatcagatcttg
Downstream sequence
tgagattcattcactatcatgagaacagcatgggaaagatccacccccatgattcaatcattttccatcgagtcccttccacaacacatggggataatgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate