Basic Information
VIS ID
TVIS10012498
Fusion event
HBV-LOC105374813 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
234
Orient
+
Integrated sequence
GATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTC| |ACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATC
Host Sequence
Chromosome
chr2
Cytoband
p12
Reference genome
GRCh37/hg19
Start
75970633/75743507 (Hg38)
End
75970633/75743507 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC105374813
Nearest miRNA
hsa-mir-1285-2/Upstream/652593; hsa-mir-10b/Downstream/3905787;
Nearest TSS
ENST00000437798/Upstream/24387; ENST00000445178/Downstream/1242458;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/32494, chr2-CpG: 32/Downstream/3249559
Nearby gene
GCFC2(-32522) ; LRRTM4(+1004217) ;
Upstream sequence
atctctacaaacactgatgaaagaaaatgaagacaatacaaacaaatgaaaagacatcccatgttcatggatcagaaaagtaaatattgctaaatttaca
Downstream sequence
atactactcaaagcaatctacagatccaatgcaattcctatgaaatcatcaattgcattcttcatagaaatggaaaaaatcctgaaatttctatggaacc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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