Basic Information
VIS ID
TVIS10012503
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1414
Orient
+
Integrated sequence
GAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGG| |GACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGA
Host Sequence
Chromosome
chr2
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
99818081/99201618 (Hg38)
End
99818081/99201618 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA2S ; FRA2A
Nearest miRNA
hsa-mir-1285-2/Upstream/2403265; hsa-mir-10b/Downstream/2107832;
Nearest TSS
ENST00000437798/Upstream/15442; ENST00000465095/Downstream/52663;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/20458, chr2-CpG: 148/Downstream/134407
Nearby gene
MRPL30(-2061) ; LYG2(+40630) ;
Upstream sequence
CCATGCTTCCGGGACATCCTCCTGGTCTTGACAGTGGTGAAAATCTGGATGTCATGAATTCTGTGGCCTGACTTCACCTGCCCTTGACTAAAGAGGGGGA
Downstream sequence
Ttgaggaaaagaaaaagcaacttctgacagccaggaactggcctggaactctcaggccttggtgtttccaggagctggcctggcctcacaggtggtgttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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