Basic Information
VIS ID
TVIS10012507
Fusion event
HBV-TAFA5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1917
Orient
+
Integrated sequence
GCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCT| |TATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATC
Host Sequence
Chromosome
chr22
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
49082817/48687005 (Hg38)
End
49082817/48687005 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
TAFA5
Nearest miRNA
hsa-let-7a-3/Upstream/412590; hsa-mir-12114/Downstream/93290;
Nearest TSS
ENST00000624155/Upstream/110552; ENST00000406880/Downstream/6242;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/7277, chr22-CpG: 17/Downstream/5941
Upstream sequence
ggatggatggatggatggatggatggatggatggattggtggagggtgggtgatgaatgagtgaattgatggatgggaggatagatgatggatggttgga
Downstream sequence
tggtggacaagtggatggatggatggattgatggaggatggatagatggatgaatggattgatgaatgggtggatggatggatggatagatggtgatggt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate