Basic Information
VIS ID
TVIS10012509
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2190
Orient
+
Integrated sequence
GGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAG| |TTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTC
Host Sequence
Chromosome
chr22
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
50359905/49966257 (Hg38)
End
50359905/49966257 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-3/Upstream/3318; hsa-mir-12114/Downstream/441185;
Nearest TSS
ENST00000624155/Upstream/5489; ENST00000475190/Downstream/42435;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/2690, chr22-CpG: 141/Downstream/4626
Nearby gene
PIM3(-2185) ; IL17REL(+73037) ;
Nearest cancer related gene
PIM3(OG, -2185) ;
Upstream sequence
CCCCCTCCAGCCCCCCAGCTGTCTGGGCTCCTGCACACCCTTCCCCTAGACACTCCCTGGGGCTCTGGCAGGATCCAAGTGACCGTAGGCCTGGTTCCTC
Downstream sequence
CCCGCCAGTCCCCACCCTAGACCTGCGGTCTGGCCTCTCCCTGGGGGTCGAAGCCCAGCAGAATCCACTGTGTTCCTGCAGGGCCTCTGTGGGCTCCTAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate