Basic Information
VIS ID
TVIS10012510
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2436
Orient
+
Integrated sequence
GACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCT| |CGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACA
Host Sequence
Chromosome
chr3
Cytoband
q23
Reference genome
GRCh37/hg19
Start
141188454/141469612 (Hg38)
End
141188454/141469612 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/7031706; hsa-mir-1224/Downstream/10096264;
Nearest TSS
ENST00000440867/Upstream/22718; ENST00000515549/Downstream/17435;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/66776, chr3-CpG: 16/Downstream/17085
Nearby gene
ZBTB38(-19822) ; RASA2(+17472) ;
Upstream sequence
TTTATCATTTTATTTTATCACCCTTCTTTTTTGACACAGATGAATTCCACTGGGGTGGTGAAGGTGAGAACACTGCTACAAACAATTCCAGGAATACACC
Downstream sequence
tctcgtttcatccatgctgctgcaagtgacaggatttcattcttttttatgacggagttgtatttcattgtgtatatataccatattttctttatccata
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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