Basic Information
VIS ID
TVIS10012514
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
970
Orient
+
Integrated sequence
TAAATTTTATGGGTTATGTCATTGGATGTTATGGGTCCTTGCCACAAGAACACATCATACAAAAAATCAAAGAATGTTTTAGAAAACTTCCTATTAACAG| |GCCTATTGATTGGAAAGTATGTCAACGAATTGTGGGTCTTTTGGGTTTTGCTGCCCCTTTTACACAATGTGGTTATCCTGCGTTGATGCCTTTGTATGCA
Host Sequence
Chromosome
chr4
Cytoband
q32.3
Reference genome
GRCh37/hg19
Start
166602910/165681758 (Hg38)
End
166602910/165681758 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/295421; hsa-mir-1305/Downstream/5504426;
Nearest TSS
ENST00000502981/Upstream/263532; ENST00000507838/Downstream/2881;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/302242, chr4-CpG: 78/Downstream/191635
Nearby gene
CPE(-183428) ; TLL1(+191500) ;
Upstream sequence
tgataggagcaccaaccctattataaactgcatgtggaagtgatctaggttgtgtgctccttatgagaatctaatgcctgatgatctgtcactgtttccc
Downstream sequence
acccatcaaccaacaagtagctgaagaaaatgaggtatatatactacatggaattctactcagccattaaaaaagaatgaaataatgtccttttcagtaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate