Basic Information
VIS ID
TVIS10012519
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1707
Orient
-
Integrated sequence
GCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATA| |CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
9671023/9669399 (Hg38)
End
9671023/9669399 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA4A
Nearest miRNA
hsa-mir-378d-1/Upstream/113083; hsa-mir-12113/Downstream/409212;
Nearest TSS
ENST00000502981/Upstream/224865; ENST00000304374/Downstream/112281;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/136498, chr4-CpG: 21/Downstream/22359
Nearby gene
MIR548I2(-113086) ; DRD5(+112235) ;
Upstream sequence
GCTGCCATAGCTTACTTGGGGACTACAGACAGCTCACTTGTGCAAGTAATTCAGGCACTCCTCTAATTCTCATCTCTTTTTGCCCAGGCATTCAGATTGC
Downstream sequence
accacctagagatggaattatccagttgcaggaaaacaagtgcagggctcccactgattctacattgtggtgagttgtataaggatttcattatatatta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate