Basic Information
VIS ID
TVIS10012521
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
492
Orient
+
Integrated sequence
TTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGA| |TCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAA
Host Sequence
Chromosome
chr5
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
129935910/130600217 (Hg38)
End
129935910/130600217 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA5C
Nearest miRNA
hsa-mir-10397/Upstream/1203070; hsa-mir-103a-1/Downstream/1617632;
Nearest TSS
ENST00000502646/Upstream/692130; ENST00000507584/Downstream/562410;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/694298, chr5-CpG: 27/Downstream/394861
Nearby gene
CHSY3(-413583) ; HINT1(+558965) ;
Nearest cancer related gene
HINT1(TSG, +558965) ;
Upstream sequence
CACTGTGTTAGGCACTAAGCATAAGAAAATAAGAGAAGGTCGCCCTGCCAGTAGTTAGAATTCAGTTAAGGAAATAAAACATATGCACAGAAATAAACAT
Downstream sequence
AAAGAATATAGAAGGCCTACAAAAAGTCTTTTTTGaaaatgggtaaaatgcataatcatctattttgaagaagaaaaaacacatgctcaacaaacataga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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