ADAMTS12 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10012523
Fusion event
HBV-ADAMTS12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3153
Orient
-
Integrated sequence
CAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGA| |GAAACACTCATCCTCAGGCCATGCAGTGG
Host Sequence
Chromosome
chr5
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
33877302/33877197 (Hg38)
End
33877302/33877197 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
ADAMTS12
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10397/Upstream/1482722; hsa-mir-103a-1/Downstream/2270695;
Nearest TSS
ENST00000502646/Upstream/36885; ENST00000330120/Downstream/14411;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/374939, chr5-CpG: 25/Downstream/14889
Upstream sequence
ctgaatactggttctgctccttctatctgtgagaatgtgggcaaactatttaaattctttaaaactgcaatttcctctttcataaaaaaaattgcaatta
Downstream sequence
CTAAGAAATGCTATGAACAGGAATTACATAATGTGCTATAAACAGAAATTAAAATTATAAGTTTAATGACCCAGGTACACAGTCCAGAGGATAAGTGCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate